Case Study – Sonication for Pharmaceutical Solutions

Customer

A fully integrated pharmaceutical organization having a global presence. The organization is primarily working on the CMO (contract manufacturing organization) and CDMO (contract development and manufacturing organization) business of pharmaceutical preparations in various dosage forms.

Problem

• The customer is processing a large number of liquid samples on a daily basis
• They are looking to improve the process on the following parameters:
  • Speed up reaction
  • Improve the output of the reaction
  • Improve the catalyst performance
  • Improve the reactivity of the reagents
  • Improve the synthesis of the particles used
• A huge variety of samples are to be sonicated simultaneously
• The samples are placed in beakers, vials and flasks of various sizes
• A robust equipment is required to effectively sonicate samples daily without any breakdown
• Ralsonics was chosen to manufacture this equipment due to long standing track record of manufacturing reliable and high quality sonicators for the pharmaceutical sector

Ralsonics’ Solution

• Ralsonics’ design team gained a complete understanding of the varieties and volume of containers that were to be sonicated daily
• Based on this, a customized holding fixture was designed
• The designs were iterated and improved upon after customer inputs were provided
• The sonication equipment was designed specifically for the processing volume of the customer
• Necessary features were added to ensure that consistent and cold-spot free sonication takes place throughout the bath
• The equipment took into account the special requirements of customers in the pharmaceutical sector

Results

• The scientists using the equipment were very satisfied with the sonication observed
• Complete IQ, OQ, PQ protocols were observed and implemented to the satisfaction of the scientists
• Orders for more such equipment were placed within 2 months

Customer Comments

“The sonication observed in this equipment is far more than what we were using previously”

Other applications of this solution

• Chemical mixing applications
• Mixing of powder into liquids for the food industry
• Degassing and deaeration in viscous liquids
• Dispersion of pigment powders in liquids
• Consistent deagglomeration
• Applications that require extraction using ultraosnics

Contact us to learn more about how we can help you with your sonochemistry applications